Lower extremity lesions in a female with Graves’ disease

Presenter: Cherise Khani, DO

Dermatology Program: St. Barnabas Hospital

CHIEF COMPLAINT: Swelling of bilateral lower extremities x 2 years and “raised circles on right shin and toes” x 9 months

CLINICAL HISTORY: A 44 year-old female presented with swelling of her bilateral lower extremities x 2 years, and “raised circles on right shin and toes” x 9 months. Lesions of the right lower extremity were associated only with mild intermittent pruritus. The patient denied pain, numbness, or paresthesias of affected area. She was diagnosed with Graves’ disease in 2009 and successfully treated with radioactive iodine. Resultant hypothyroidism has been well controlled with levothyroxine, without recurrence of symptoms. The patient had a recent surgical excision of masses on right and left great toes, as well as degenerated sesamoid bone of the right foot. The surgical pathology demonstrated benign fibroconnective tissue, showing a myxoid-mucoid background.

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Enlarging growth on the foot of a teenage boy

Presenter: Holly Kanavy, DO

Dermatology Program: St. Barnabas Hospital

CHIEF COMPLAINT: growth on the bottom of his left foot

CLINICAL HISTORY: 14 yo Caucasian male presented with growth on the bottom of his left foot for 3-4 months. He also endorses pain with ambulation. Previously, he had a series of curettages by podiatry, however the lesion continued to enlarge. Patient has a history of chronic macrocytosis and reticulocytopenia (bone marrow biopsy at age 10 revealed a non-clonal chromosome 15 deletion: 45 XY del(15)(q11.2)), developmental abnormalities, and Autism / Asperger’s disease.

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Progressive stiffening of skin

Presenter: Kate Kleydman, DO

Dermatology Program: Saint. Barnabas Hospital

CHIEF COMPLAINT:  “My skin is so stiff.”

CLINICAL HISTORY: A 52-year-old African-American female presented with complaints of having “stiff skin” that progressively impaired her movement over the past five years. The skin “tightness” had started on the body, and then progressed to include her hands, trunk, legs, and finally face. She complained of constant pain, with restrictions of movement requiring the use of a walker. She experienced worsening of the pain in her hands, accompanied by color changes and tingling in cold weather. Her review of systems was positive for difficulty swallowing, acid reflux, dyspnea on exertion, nonproductive cough, diffuse arthralgias and myalgias, subjective decreased range of motion, and chronic fatigue. No previous treatment. Her past medical history was significant for hypertension and gastroesophageal reflux disease. The patient was taking Lisinopril and Percocet and denied alcohol and drug use. Her family history was negative for any significant dermatologic diseases or autoimmune disorders.

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Large yellow plaque on the tongue

Presenter: Shaheen Oshtory, D.O., Charles Gropper, M.D., Cindy Hoffman, D.O.

Dermatology Program: Saint Barnabas Hospital

CHIEF COMPLAINT:  “My tongue hurts”

CLINICAL HISTORY: A 75 y/o female was admitted to St. Barnabas Hospital for metastatic malignant ascites secondary to vaginal cancer. On admission, she also complained of pain on her tongue and of a large, yellow plaque that had been present for several months. She denied any previous treatment. Her past medical history was significant for DM, HTN, chronic LBP, osteoporosis, bladder incontinence, and vaginal Cancer. Her current medications included Alendronate, Nexium, Neurontin, Lisinopril, Reglan, Etoprolol, MS Contin, Oxybutynin, and Zocor.

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Persistent plaques after bone marrow transplant

Presenter: Risa Gorin, DO

Dermatology Program: St. Barnabas Hospital Dermatology Department, Bronx, New York

CHIEF COMPLAINT:  persistent rash for 7 years

CLINICAL HISTORY: A 19 yr old Hispanic male with a seven-year history of a persistent rash presented to our clinic. The lesions began on his proximal extremities and increased in number and size over time. The lesions began one year after allogeneic bone marrow transplant for acute myelogenous leukemia. However, he stated that he was not taking any immunosuppressants when the rash started. The lesions were occasionally pruritic and unresponsive to super-high potency topical steroids. Family history was non-contributory. Patient was not taking any medications at the time of presentation to our office. 

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