Presenter: Jennifer Peterson DO, Angelo Petropolis MD, Amy Weierman PA-C
Dermatology Program: Advanced Desert Dermatology
Program Director: Vernon T Mackey DO
Submitted on: August 30, 2015
CHIEF COMPLAINT: Odd blotchiness on legs
CLINICAL HISTORY: A 65-year-old Caucasian female presented for evaluation of odd blotchiness on her legs. The patient reported onset of blotchiness on her legs approximately 1 month prior to presentation. She denied any local or constitutional symptoms associated with skin lesions. No history of recent travel or medication changes. Her past medical history is significant for hypothyroidism (controlled on levothyroxine), chronic arthritis, morbid obesity status-post gastric bypass surgery (with subsequent profound weight loss), and anemia secondary to malabsorption. A 10-point review of systems was performed, and did not reveal any new, evolving, or unexplained signs or symptoms.
PHYSICAL EXAM:
Physical examination revealed multiple focal pink to purple macules and flaccid papules with a thin, wrinkled surface, clustered in a regular reticular pattern on the bilateral anterior and medial thighs and lower legs. Lesions exhibited a positive buttonhole sign on compression.
LABORATORY TESTS:
Done following biopsy; see Treatment section below.
DERMATOHISTOPATHOLOGY:
Two 4 mm punch biopsies were obtained from lesions on the right thigh. Sections showed an unremarkable epidermis and dermis, however, an elastic tissue stain demonstrated mild diminution of elastic fibers in one of the specimens.
DIFFERENTIAL DIAGNOSIS:
1. Generalized granuloma annulare
2. Granulomatous slack skin
3. Papular elastorrhexis
4. Anetoderma
5. Atrophoderma of Pasini and Pierini