Generalized blisters after nivolumab treatment

Presenter: Alyson Ridpath, DO PGY-3
Dermatology Program: OhioHealth O’Bleness
Program Director: Dawn Sammons, DO, FAOCD
Submitted on: Feb 21, 2018

CHIEF COMPLAINT:  A 67-year-old male with stage IV BRAF- and c-Kit-negative, NRAS-positive melanoma of unknown primary with metastases to the liver, lung and brain was started on nivolumab 3 mg/kg every two weeks.

CLINICAL HISTORY:

Signs and symptoms:  After 16 cycles over 32 weeks, he presented to the emergency department with a new, severe, pruritic, bullous eruption covering approximately 90% body surface area, and altered mental status

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Recurrent erythematous papules and nodules on the back of right lower leg

Presenter: Richard Winkelmann, DO; Jessica Hoy, DO; Kylee Sacksteder, DO; Gabriella Maloney, DO; Alyson Ridpath, DO
Dermatology Program: OhioHealth Dermatology Columbus, OH
Program Director: Dawn Sammons, DO
Submitted on: May 5, 2017

CHIEF COMPLAINT:  Recurrent bumps on back of right lower leg

CLINICAL HISTORY:

Signs and symptoms:  A 64-year-old immunocompetent female presented with a seven-month history of recurrent erythematous papules and nodules on the back of her right lower leg. She reported that the nodules were tender, nonpruritic, and, at times, had a clear exudate. The patient denied any trauma to the area and initially attributed the eruption to mosquito bites.

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